Protein Science Facility (PSF)

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SciLifeLab Infrastructure Unit 2013–2020.

Primary: Shown in the list of current labels.

Year 2020

PubMed DOI Crossref
Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring-An Inactive Enzyme with Intact Substrate Binding.
Gustafsson R, Eckhard U, Ye W, ..., Andersson L, Selmer M
Biomolecules 10 (12) - [2020-12-03; online 2020-12-03]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Esomeprazole reduces sperm motility index by targeting the spermic cholinergic machinery: A mechanistic study for the association between use of proton pump inhibitors and reduced sperm motility index.
Kumar A, Kumar R, Flanagan J, ..., Björndahl L, Darreh-Shori T
Biochem. Pharmacol. 182 (-) 114212 [2020-12-00; online 2020-08-28]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
A ribonucleotide reductase from Clostridium botulinum reveals distinct evolutionary pathways to regulation via the overall activity site.
Martínez-Carranza M, Jonna VR, Lundin D, ..., Stenmark P, Hofer A
J. Biol. Chem. 295 (46) 15576-15587 [2020-11-13; online 2020-09-03]
Bioinformatics Support for Computational Resources [Service] Cryo-EM [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins.
Nowak K, Rosenthal F, Karlberg T, ..., Leslie Pedrioli DM, Hottiger MO
Nat Commun 11 (1) 5199 [2020-10-15; online 2020-10-15]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility.
Navarro C, Lyu J, Katsori AM, Caridha R, Elsässer SJ
Nat Commun 11 (1) 5095 [2020-10-09; online 2020-10-09]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Mitigation of the replication of SARS-CoV-2 by nitric oxide in vitro.
Akaberi D, Krambrich J, Ling J, ..., Lennerstrand J, Lundkvist Å
Redox Biol 37 (-) 101734 [2020-10-00; online 2020-09-21]
Bioinformatics Support for Computational Resources [Service] Chemical Biology Consortium Sweden (CBCS) [Service] Drug Discovery and Development (DDD) [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Development of a chemical probe against NUDT15.
Zhang SM, Desroses M, Hagenkort A, ..., Stenmark P, Helleday T
Nat. Chem. Biol. 16 (10) 1120-1128 [2020-10-00; online 2020-07-20]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.
Hanke L, Vidakovics Perez L, Sheward DJ, ..., Murrell B, McInerney GM
Nat Commun 11 (1) 4420 [2020-09-04; online 2020-09-04]
Bioinformatics Support for Computational Resources [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Defining the proteolytic landscape during enterovirus infection.
Saeed M, Kapell S, Hertz NT, ..., Molina H, Rice CM
PLoS Pathog. 16 (9) e1008927 [2020-09-00; online 2020-09-30]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
Škerlová J, Unterlass J, Göttmann M, ..., Jemth AS, Stenmark P
J. Biol. Chem. 295 (33) 11656-11668 [2020-08-14; online 2020-06-22]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
MrpH, a new class of metal-binding adhesin, requires zinc to mediate biofilm formation.
Jiang W, Ubhayasekera W, Breed MC, ..., Pearson MM, Knight SD
PLoS Pathog. 16 (8) e1008707 [2020-08-00; online 2020-08-11]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
A robust and versatile method for production and purification of large-scale RNA samples for structural biology.
Karlsson H, Baronti L, Petzold K
RNA 26 (8) 1023-1037 [2020-08-00; online 2020-04-30]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
A Transmembrane Crenarchaeal Mannosyltransferase Is Involved in N-Glycan Biosynthesis and Displays an Unexpected Minimal Cellulose-Synthase-like Fold.
Gandini R, Reichenbach T, Spadiut O, ..., Kalyani DC, Divne C
J. Mol. Biol. 432 (16) 4658-4672 [2020-07-24; online 2020-06-19]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Arachidonic acid promotes the binding of 5-lipoxygenase on nanodiscs containing 5-lipoxygenase activating protein in the absence of calcium-ions.
Kumar RB, Purhonen P, Hebert H, Jegerschöld C
PLoS ONE 15 (7) e0228607 [2020-07-09; online 2020-07-09]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Proton pump inhibitors act with unprecedented potencies as inhibitors of the acetylcholine biosynthesizing enzyme-A plausible missing link for their association with incidence of dementia.
Kumar R, Kumar A, Nordberg A, Långström B, Darreh-Shori T
Alzheimers Dement 16 (7) 1031-1042 [2020-07-00; online 2020-05-08]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA.
Baronti L, Guzzetti I, Ebrahimi P, ..., Chen AA, Petzold K
Nature 583 (7814) 139-144 [2020-07-00; online 2020-05-27]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
In silico Druggability Assessment of the NUDIX Hydrolase Protein Family as a Workflow for Target Prioritization.
Michel M, Homan EJ, Wiita E, ..., Helleday T, Warpman Berglund U
Front. Chem. 8 (-) 443 [2020-05-29; online 2020-05-29]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
Scaletti ER, Vallin KS, Bräutigam L, ..., Stenmark P, Jemth AS
J. Biol. Chem. 295 (15) 4761-4772 [2020-04-10; online 2020-03-06]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
The application of differential scanning fluorimetry in exploring bisubstrate binding to protein arginine N-methyltransferase 1.
Brown JI, Page BDG, Frankel A
Methods 175 (-) 10-23 [2020-03-15; online 2019-11-11]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
One-Pot Production of RNA in High Yield and Purity Through Cleaving Tandem Transcripts.
Feyrer H, Munteanu R, Baronti L, Petzold K
Molecules 25 (5) - [2020-03-04; online 2020-03-04]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death.
Busker S, Qian W, Haraldsson M, ..., Tamm KP, Page BDG
Sci Adv 6 (12) eaax7945 [2020-03-00; online 2020-03-20]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products.
Scaletti E, Claesson M, Helleday T, Jemth AS, Stenmark P
J. Mol. Biol. 432 (4) 1126-1142 [2020-02-14; online 2020-01-15]
Protein Science Facility (PSF) [Service]

Year 2019

PubMed DOI Crossref
Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease.
Akaberi D, Chinthakindi PK, Båhlström A, ..., Lundkvist Å, Lennerstrand J
J. Biomol. Struct. Dyn. 38 (18) 1-11 [2019-12-27; online 2019-12-27]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.
Nicholls TJ, Spåhr H, Jiang S, ..., Larsson NG, Gustafsson CM
Mol. Cell 76 (5) 784-796.e6 [2019-12-05; online 2019-10-03]
Bioinformatics Support for Computational Resources [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Correction: APR-246 reactivates mutant p53 by targeting cysteines 124 and 277.
Zhang Q, Bykov VJN, Wiman KG, Zawacka-Pankau J
Cell Death Dis 10 (10) 769 [2019-10-10; online 2019-10-10]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Genotyping by low-coverage whole-genome sequencing in intercross pedigrees from outbred founders: a cost-efficient approach.
Zan Y, Payen T, Lillie M, ..., Siegel PB, Carlborg Ö
Genet. Sel. Evol. 51 (1) 44 [2019-08-14; online 2019-08-14]
NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Gas-Phase Collisions with Trimethylamine-N-Oxide Enable Activation-Controlled Protein Ion Charge Reduction.
Kaldmäe M, Österlund N, Lianoudaki D, ..., Marklund EG, Landreh M
J. Am. Soc. Mass Spectrom. 30 (8) 1385-1388 [2019-08-00; online 2019-07-08]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2.
Anandapadamanaban M, Kyriakidis NC, Csizmók V, ..., Wahren-Herlenius M, Sunnerhagen M
J. Biol. Chem. 294 (30) 11404-11419 [2019-07-26; online 2019-06-03]
Protein Science Facility (PSF) [Collaborative]
PubMed DOI Crossref
Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs.
Scaletti E, Jemth AS, Helleday T, Stenmark P
FEBS Lett. 593 (14) 1863-1873 [2019-07-00; online 2019-06-10]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Crystal structure of the catalytic domain of the Weissella oryzae botulinum‐like toxin
Košenina S, Masuyer G, Zhang S, Dong M, Stenmark P
FEBS Lett 593 (12) 1403-1410 [2019-06-00; online 2019-05-31]
Bioinformatics Support for Computational Resources [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients.
Idborg H, Zandian A, Ossipova E, ..., Svenungsson E, Jakobsson PJ
Front Immunol 10 (-) 1029 [2019-05-17; online 2019-05-17]
Affinity Proteomics Stockholm [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes.
Yuen LH, Dana S, Liu Y, ..., Schüler H, Franzini RM
J. Am. Chem. Soc. 141 (13) 5169-5181 [2019-04-03; online 2019-03-19]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana.
Jemth AS, Scaletti E, Carter M, Helleday T, Stenmark P
Biochemistry 58 (7) 887-899 [2019-02-19; online 2019-01-16]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Ge C, Xu B, Liang B, ..., Dobritzsch D, Holmdahl R
Arthritis & rheumatology (Hoboken, N.J.) 71 (2) 210-221 [2019-02-00; online 2019-01-04]
Protein Science Facility (PSF) [Service]

Year 2018

PubMed DOI Crossref
Cotranslational Folding of a Pentarepeat β-Helix Protein.
Notari L, Martínez-Carranza M, Farías-Rico JA, Stenmark P, von Heijne G
J. Mol. Biol. 430 (24) 5196-5206 [2018-12-07; online 2018-10-27]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.
Visnes T, Cázares-Körner A, Hao W, ..., Boldogh I, Helleday T
Science 362 (6416) 834-839 [2018-11-16; online 2018-11-18]
Bioinformatics Support for Computational Resources [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative] Chemical Proteomics [Collaborative] Drug Discovery and Development (DDD) [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.
Jemth AS, Gustafsson R, Bräutigam L, ..., Stenmark P, Helleday T
Nucleic Acids Res. 46 (20) 10888-10904 [2018-11-16; online 2018-10-12]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Structures of two fimbrial adhesins, AtfE and UcaD, from the uropathogen Proteus mirabilis.
Jiang W, Ubhayasekera W, Pearson MM, Knight SD
Acta Crystallogr D Struct Biol 74 (Pt 11) 1053-1062 [2018-11-01; online 2018-10-29]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
E. coli HMS174(DE3) is a sustainable alternative to BL21(DE3).
Hausjell J, Weissensteiner J, Molitor C, Halbwirth H, Spadiut O
Microb. Cell Fact. 17 (1) 169 [2018-10-30; online 2018-10-30]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions.
Desroses M, Busker S, Astorga-Wells J, ..., Grandér D, Page BDG
Journal of Pharmaceutical and Biomedical Analysis 160 (-) 80-88 [2018-10-25; online 2018-07-17]
Chemical Proteomics [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Role of Thiol Reactivity for Targeting Mutant p53.
Zhang Q, Bergman J, Wiman KG, Bykov VJN
Cell Chem Biol 25 (10) 1219-1230.e3 [2018-10-18; online 2018-07-26]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Structural and biochemical characterization of the Cutibacterium acnes exo-β-1,4-mannosidase that targets the N-glycan core of host glycoproteins
Reichenbach T, Kalyani D, Gandini R, ..., Aspeborg H, Divne C
PLoS ONE 13 (9) e0204703 [2018-09-27; online 2018-09-27]
Bioinformatics Support for Computational Resources [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface.
Karlberg T, Hornyak P, Pinto AF, ..., Björkegren C, Schüler H
Nat Commun 9 (1) 3785 [2018-09-17; online 2018-09-17]
Bioinformatics Support for Computational Resources [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Structural and Functional Characterization of the BcsG Subunit of the Cellulose Synthase in Salmonella typhimurium.
Sun L, Vella P, Schnell R, ..., Schneider G, Römling U
J. Mol. Biol. 430 (18 Pt B) 3170-3189 [2018-09-14; online 2018-07-12]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
A glutaredoxin domain fused to the radical-generating subunit of ribonucleotide reductase (RNR) functions as an efficient RNR reductant.
Rozman Grinberg I, Lundin D, Sahlin M, ..., Hofer A, Sjöberg BM
J. Biol. Chem. - (-) - [2018-08-30; online 2018-08-30]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
BtsCI and BseGI display sequence preference in the nucleotides flanking the recognition sequence
Rosa J, Fernandez-Gonzalez E, Ducani C, Högberg B
PLoS ONE 13 (8) e0202057 [2018-08-17; online 2018-08-17]
NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
PrgB promotes aggregation, biofilm formation, and conjugation through DNA binding and compaction.
Schmitt A, Jiang K, Camacho MI, ..., Christie PJ, Berntsson RP
Mol. Microbiol. 109 (3) 291-305 [2018-08-00; online 2018-07-31]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Regulation of Neuronal Na,K-ATPase by Extracellular Scaffolding Proteins.
Liebmann T, Fritz N, Kruusmägi M, ..., Aperia A, Brismar H
Int J Mol Sci 19 (8) 2214 [2018-07-29; online 2018-07-29]
Bioinformatics Support for Computational Resources [Service] Integrated Microscopy Technologies Stockholm [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.
Riley AM, Unterlass J, Konieczny V, ..., Helleday T, Potter BVL
Med. Chem. Commun. 9 (7) 1105-1113 [2018-07-01; online 2018-06-04]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response.
Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J
Nat. Med. 24 (7) 927-930 [2018-07-00; online 2018-06-11]
CRISPR Functional Genomics [Collaborative] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins.
Spåhr H, Chia T, Lingford JP, ..., Filipovska A, Rackham O
Nat Commun 9 (1) 2212 [2018-06-07; online 2018-06-07]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14
Holechek J, Lease R, Thorsell AG, ..., Schüler H, Ferraris D
Bioorganic & Medicinal Chemistry Letters 28 (11) 2050-2054 [2018-06-00; online 2018-06-00]
Bioinformatics Support for Computational Resources [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Ligation of free HMGB1 to TLR2 in the absence of ligand is negatively regulated by the C-terminal tail domain.
Aucott H, Sowinska A, Harris HE, Lundback P
Mol. Med. 24 (1) 19 [2018-05-04; online 2018-05-04]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
The structure of the N-terminal module of the cell wall hydrolase RipA and its role in regulating catalytic activity.
Steiner EM, Lyngsø J, Guy JE, ..., Schneider G, Schnell R
Proteins - (-) - [2018-05-02; online 2018-05-02]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding.
Gustafsson R, Zhang S, Masuyer G, Dong M, Stenmark P
Toxins (Basel) 10 (4) - [2018-04-12; online 2018-04-12]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima.
Morgunova E, Yin Y, Das PK, ..., Nilsson L, Taipale J
Elife 7 (-) - [2018-04-11; online 2018-04-11]
Bioinformatics Support for Computational Resources [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Structural and functional studies of Spr1654: an essential aminotransferase in teichoic acid biosynthesis in
Han X, Sun R, Sandalova T, Achour A
Open Biol 8 (4) - [2018-04-00; online 2018-04-20]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Identification of Poly(ADP-Ribose) Polymerase Macrodomain Inhibitors Using an AlphaScreen Protocol
Ekblad T, Verheugd P, Lindgren AE, ..., Elofsson M, Schüler H
SLAS DISCOVERY: Advancing Life Sciences R&D 23 (4) 353-362 [2018-04-00; online 2018-01-09]
Chemical Biology Consortium Sweden (CBCS) [Service] Protein Science Facility (PSF) [Collaborative]
PubMed DOI Crossref
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.
Ladds MJGW, van Leeuwen IMM, Drummond CJ, ..., McCormack E, Laín S
Nat Commun 9 (1) 1107 [2018-03-16; online 2018-03-16]
Bioinformatics Support for Computational Resources [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability.
Hafstrand I, Doorduijn EM, Sun R, ..., van Hall T, Achour A
J. Immunol. - (-) - [2018-03-05; online 2018-03-05]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.
Stafford WC, Peng X, Olofsson MH, ..., Linder S, Arnér ESJ
Sci Transl Med 10 (428) - [2018-02-14; online 2018-02-16]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold.
Carter M, Jemth AS, Carreras-Puigvert J, ..., Helleday T, Stenmark P
Structure 26 (2) 295-303.e6 [2018-02-06; online 2018-02-08]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
Narwal M, Jemth AS, Gustafsson R, ..., Helleday T, Stenmark P
Biochemistry 57 (5) 593-603 [2018-02-06; online 2018-01-16]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit.
Rozman Grinberg I, Lundin D, Hasan M, ..., Logan DT, Sjöberg BM
Elife 7 (-) - [2018-02-01; online 2018-02-01]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Probing the activity of a recombinant Zn2+ -transporting P-type ATPase.
Ravishankar H, Barth A, Andersson M
Biopolymers 109 (2) - [2018-02-00; online 2017-11-23]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Page BDG, Valerie NCK, Wright RHG, ..., Beato M, Helleday T
Nat Commun 9 (1) 250 [2018-01-17; online 2018-01-17]
Bioinformatics Support for Computational Resources [Service] Drug Discovery and Development (DDD) [Service] Protein Science Facility (PSF) [Service]

Year 2017

PubMed DOI Crossref
InSiDDe: A Server for Designing Artificial Disordered Proteins.
Schramm A, Lieutaud P, Gianni S, Longhi S, Bignon C
Int J Mol Sci 19 (1) - [2017-12-29; online 2017-12-29]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Structural basis for dolichylphosphate mannose biosynthesis
Gandini R, Reichenbach T, Tan TC, Divne C
Nat Commun 8 (1) - [2017-12-00; online 2017-07-25]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1
Lehmann LC, Hewitt G, Aibara S, ..., Boulton SJ, Deindl S
Molecular Cell 68 (5) 847-859.e7 [2017-12-00; online 2017-12-00]
Cryo-EM [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
Carreras-Puigvert J, Zitnik M, Jemth AS, ..., Zupan B, Helleday T
Nat Commun 8 (1) - [2017-12-00; online 2017-11-16]
BioImage Informatics [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance
Petrus P, Bialesova L, Checa A, ..., Gao H, Rydén M
- - (-) - [2017-11-07; online 2017-11-07]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51.
Kumar R, Moche M, Winblad B, Pavlov PF
Sci Rep 7 (1) 14288 [2017-10-27; online 2017-10-27]
Protein Science Facility (PSF) [Collaborative]
PubMed DOI Crossref
Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX type gene cluster.
Gustafsson R, Berntsson RP, Martínez-Carranza M, ..., Johnson EA, Stenmark P
FEBS Lett. - (-) - [2017-10-25; online 2017-10-25]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Entirely enzymatic nanofabrication of DNA–protein conjugates
Bernardinelli G, Högberg B
Nucleic Acids Res 45 (18) e160-e160 [2017-10-13; online 2017-08-16]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Profiling of in vitro activities of urea-based inhibitors against cysteine synthases from Mycobacterium tuberculosis.
Brunner K, Steiner EM, Reshma RS, ..., Schnell R, Schneider G
Bioorg. Med. Chem. Lett. 27 (19) 4582-4587 [2017-10-01; online 2017-08-19]
Chemical Biology Consortium Sweden (CBCS) [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Correction to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.
Llona-Minguez S, Höglund A, Ghassemian A, ..., Scobie M, Helleday T
J. Med. Chem. 60 (17) 7614 [2017-09-14; online 2017-09-01]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Capturing LTA 4 hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB4 synthesis.
Stsiapanava A, Samuelsson B, Haeggström JZ
Proc. Natl. Acad. Sci. U.S.A. 114 (36) 9689-9694 [2017-09-05; online 2017-08-21]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Mucin-Inspired Lubrication on Hydrophobic Surfaces
Käsdorf BT, Weber F, Petrou G, ..., Crouzier T, Lieleg O
Biomacromolecules 18 (8) 2454-2462 [2017-08-14; online 2017-07-03]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Investigation of calcium-dependent activity and conformational dynamics of zebra fish 12-lipoxygenase
Mittal M, Hasan M, Balagunaseelan N, ..., Haeggström JZ, Rinaldo-Matthis A
Biochimica et Biophysica Acta (BBA) - General Subjects 1861 (8) 2099-2111 [2017-08-00; online 2017-08-00]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Biophysical characterization of the calmodulin-like domain of Plasmodium falciparum calcium dependent protein kinase 3
Andresen C, Niklasson M, Cassman Eklöf S, Wallner B, Lundström P
PLoS ONE 12 (7) e0181721 [2017-07-26; online 2017-07-26]
Protein Science Facility (PSF) [Service] Swedish NMR Centre (SNC) [Service]
PubMed DOI Crossref
Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
Ge C, Tong D, Liang B, ..., Dobritzsch D, Holmdahl R
JCI Insight 2 (13) - [2017-07-06; online 2017-07-06]
Autoimmunity and Serology Profiling [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14
Upton K, Meyers M, Thorsell AG, ..., Schüler H, Ferraris D
Bioorganic & Medicinal Chemistry Letters 27 (13) 2907-2911 [2017-07-00; online 2017-07-00]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.
Llona-Minguez S, Höglund A, Ghassemian A, ..., Scobie M, Helleday T
J. Med. Chem. 60 (10) 4279-4292 [2017-05-25; online 2017-05-16]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Impact of cytosine methylation on DNA binding specificities of human transcription factors
Yin Y, Morgunova E, Jolma A, ..., Vinson C, Taipale J
Science 356 (6337) eaaj2239 [2017-05-05; online 2017-05-04]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
SnoN Stabilizes the SMAD3/SMAD4 Protein Complex
Walldén K, Nyman T, Hällberg BM
Sci Rep 7 (-) 46370 [2017-04-11; online 2017-04-11]
Protein Science Facility (PSF) [Collaborative]
PubMed DOI Crossref
Structure determination of a major facilitator peptide transporter: Inward facing PepTSt from Streptococcus thermophilus crystallized in space group P3121.
Quistgaard EM, Martinez Molledo M, Löw C
PLoS ONE 12 (3) e0173126 [2017-03-06; online 2017-03-06]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy
B. Kumar R, Zhu L, Hebert H, Jegerschöld C
J Vis Exp - (121) - [2017-03-05; online 2017-03-05]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Binding and processing of β-lactam antibiotics by the transpeptidase LdtMt2fromMycobacterium tuberculosis
Steiner EM, Schneider G, Schnell R
FEBS J 284 (5) 725-741 [2017-03-00; online 2017-02-08]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Characterization of the Ruler Protein Interaction Interface on the Substrate Specificity Switch Protein in the Yersinia Type III Secretion System.
Ho O, Rogne P, Edgren T, ..., Login FH, Wolf-Watz M
J. Biol. Chem. 292 (8) 3299-3311 [2017-02-24; online 2016-12-30]
Protein Science Facility (PSF) [Service] Swedish NMR Centre (SNC) [Service]
PubMed DOI Crossref
Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors
Thorsell AG, Ekblad T, Karlberg T, ..., Cohen MS, Schüler H
J. Med. Chem. 60 (4) 1262-1271 [2017-02-23; online 2016-12-21]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
Herold N, Rudd SG, Ljungblad L, ..., Helleday T, Schaller T
Nat. Med. 23 (2) 256-263 [2017-02-00; online 2017-01-09]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Small Molecule Microarray Based Discovery of PARP14 Inhibitors
Peng B, Thorsell AG, Karlberg T, Schüler H, Yao SQ
Angew. Chem. Int. Ed. 56 (1) 248-253 [2017-01-02; online 2016-12-05]
Protein Science Facility (PSF) [Service]

Year 2016

PubMed DOI Crossref
A ribonucleotide reductase inhibitor with deoxyribonucleoside-reversible cytotoxicity.
Crona M, Codó P, Jonna VR, ..., Fernandes AP, Tholander F
Mol Oncol 10 (9) 1375-1386 [2016-11-00; online 2016-07-26]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice.
Lundbäck P, Lea JD, Sowinska A, ..., Antoine DJ, Erlandsson Harris H
Hepatology 64 (5) 1699-1710 [2016-11-00; online 2016-09-01]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Generation and analyses of human synthetic antibody libraries and their application for protein microarrays.
Säll A, Walle M, Wingren C, ..., Borrebaeck CAK, Persson H
Protein Eng. Des. Sel. 29 (10) 427-437 [2016-10-00; online 2016-09-01]
Drug Discovery and Development (DDD) [Technology development] Protein Science Facility (PSF) [Collaborative]
PubMed DOI Crossref
Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD.
Quistgaard EM, Weininger U, Ural-Blimke Y, ..., Akke M, Löw C
BMC Biol. 14 (1) 82 [2016-09-23; online 2016-09-23]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.
Valerie NC, Hagenkort A, Page BD, ..., Jemth AS, Helleday T
Cancer Res. 76 (18) 5501-5511 [2016-09-15; online 2016-08-16]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation.
Schulte T, Mikaelsson C, Beaussart A, ..., Nygren PÅ, Achour A
Sci Rep 6 (-) 32371 [2016-09-01; online 2016-09-01]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity.
Sandalova T, Lee M, Henriques-Normark B, ..., Mellroth P, Achour A
Mol. Microbiol. 101 (6) 954-967 [2016-09-00; online 2016-07-05]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Mutation-Induced Population Shift in the MexR Conformational Ensemble Disengages DNA Binding: A Novel Mechanism for MarR Family Derepression.
Anandapadamanaban M, Pilstål R, Andresen C, ..., Wallner B, Sunnerhagen M
Structure 24 (8) 1311-1321 [2016-08-02; online 2016-07-14]
Protein Science Facility (PSF) [Collaborative]
PubMed DOI Crossref
Kinetic investigation of human 5-lipoxygenase with arachidonic acid.
Mittal M, Kumar RB, Balagunaseelan N, ..., Haeggström JZ, Rinaldo-Matthis A
Bioorg. Med. Chem. Lett. 26 (15) 3547-3551 [2016-08-01; online 2016-06-11]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.
Brunner K, Maric S, Reshma RS, ..., Schnell R, Schneider G
J. Med. Chem. 59 (14) 6848-6859 [2016-07-28; online 2016-07-13]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Identification of Inhibitors of Pseudomonas aeruginosa Exotoxin-S ADP-Ribosyltransferase Activity.
Pinto AF, Ebrahimi M, Saleeb M, ..., Elofsson M, Schüler H
J Biomol Screen 21 (6) 590-595 [2016-07-00; online 2016-02-05]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication.
Schulte T, Liu L, Panas MD, ..., Achour A, McInerney GM
Open Biol 6 (7) - [2016-07-00; online 2016-07-08]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Coxsackievirus counters the host innate immune response by blocking type III interferon expression.
Lind K, Svedin E, Domsgen E, ..., Moll M, Flodström-Tullberg M
J. Gen. Virol. 97 (6) 1-12 [2016-06-00; online 2016-03-02]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Siitonen V, Selvaraj B, Niiranen L, ..., Schneider G, Metsä-Ketelä M
Proc. Natl. Acad. Sci. U.S.A. 113 (19) 5251-5256 [2016-05-10; online 2016-04-25]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis.
Kouznetsova E, Kanno T, Karlberg T, ..., Sjögren C, Schüler H
Structure 24 (5) 789-796 [2016-05-03; online 2016-04-21]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Novel mode of inhibition by D-tagatose 6-phosphate through a Heyns rearrangement in the active site of transaldolase B variants.
Stellmacher L, Sandalova T, Schneider S, ..., Sprenger GA, Samland AK
Acta Crystallogr D Struct Biol 72 (Pt 4) 467-476 [2016-04-00; online 2016-03-24]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Engineering a thermostable Halothermothrix orenii β-glucosidase for improved galacto-oligosaccharide synthesis.
Hassan N, Geiger B, Gandini R, ..., Divne C, Tan TC
Appl. Microbiol. Biotechnol. 100 (8) 3533-3543 [2016-04-00; online 2015-12-02]
Protein Science Facility (PSF)
PubMed DOI Crossref
A saposin-lipoprotein nanoparticle system for membrane proteins.
Frauenfeld J, Löving R, Armache JP, ..., Cheng Y, Nordlund P
Nat. Methods 13 (4) 345-351 [2016-04-00; online 2016-03-07]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.
Almqvist H, Axelsson H, Jafari R, ..., Lundbäck T, Nordlund P
Nat Commun 7 (-) 11040 [2016-03-24; online 2016-03-24]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
Mills SJ, Silvander C, Cozier G, ..., Nordlund P, Potter BV
Biochemistry 55 (9) 1384-1397 [2016-03-08; online 2016-02-29]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer.
Hafstrand I, Doorduijn EM, Duru AD, ..., van Hall T, Achour A
J. Immunol. 196 (5) 2327-2334 [2016-03-01; online 2016-01-22]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a--an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity.
Lim SM, Yeung K, Trésaugues L, Ling TH, Nordlund P
FEBS J. 283 (6) 1107-1123 [2016-03-00; online 2016-02-05]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.
Llona-Minguez S, Höglund A, Jacques SA, ..., Scobie M, Helleday T
J. Med. Chem. 59 (3) 1140-1148 [2016-02-11; online 2016-01-27]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Fuzzy regions in an intrinsically disordered protein impair protein-protein interactions.
Gruet A, Dosnon M, Blocquel D, ..., Longhi S, Bignon C
FEBS J. 283 (4) 576-594 [2016-02-00; online 2016-01-12]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Crystal structure of the flavoenzyme PA4991 from Pseudomonas aeruginosa.
Jacewicz A, Schnell R, Lindqvist Y, Schneider G
Acta Crystallogr F Struct Biol Commun 72 (Pt 2) 105-111 [2016-02-00; online 2016-01-22]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E2 synthase.
Brock JS, Hamberg M, Balagunaseelan N, ..., Rinaldo-Matthis A, Haeggström JZ
Proc. Natl. Acad. Sci. U.S.A. 113 (4) 972-977 [2016-01-26; online 2016-01-11]
Protein Science Facility (PSF) [Service]

Year 2015

PubMed DOI Crossref
Exploring water as building bricks in enzyme engineering.
Hendil-Forssell P, Martinelle M, Syrén PO
Chem. Commun. (Camb.) 51 (97) 17221-17224 [2015-12-18; online 2015-10-02]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural insights into the DNA-binding specificity of E2F family transcription factors.
Morgunova E, Yin Y, Jolma A, ..., Nilsson L, Taipale J
Nat Commun 6 (1) 10050 [2015-12-03; online 2015-12-03]
Karolinska High Throughput Center (KHTC) Protein Science Facility (PSF)
PubMed DOI Crossref
DNA-dependent formation of transcription factor pairs alters their binding specificity.
Jolma A, Yin Y, Nitta KR, ..., Morgunova E, Taipale J
Nature 527 (7578) 384-388 [2015-11-19; online 2015-11-10]
Karolinska High Throughput Center (KHTC) Protein Science Facility (PSF)
PubMed DOI Crossref
Growth of Chitinophaga pinensis on Plant Cell Wall Glycans and Characterisation of a Glycoside Hydrolase Family 27 β-l-Arabinopyranosidase Implicated in Arabinogalactan Utilisation.
McKee LS, Brumer H
PLoS ONE 10 (10) e0139932 [2015-10-08; online 2015-10-08]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity.
Ahmad S, Thulasingam M, Palombo I, ..., Haeggström JZ, Rinaldo-Matthis A
Biochim. Biophys. Acta 1854 (10 Pt A) 1365-1371 [2015-10-00; online 2015-06-13]
Protein Science Facility (PSF)
DOI Crossref
Acid-Base Catalyst Discriminates between a Fructose 6-Phosphate Aldolase and a Transaldolase
Stellmacher L, Sandalova T, Leptihn S, ..., Sprenger GA, Samland AK
ChemCatChem 7 (19) 3140-3151 [2015-10-00; online 2015-08-06]
Protein Science Facility (PSF)
PubMed DOI Crossref
Half-of-the-Sites Reactivity of the Castor Δ9-18:0-Acyl Carrier Protein Desaturase.
Liu Q, Chai J, Moche M, ..., Lindqvist Y, Shanklin J
Plant Physiol. 169 (1) 432-441 [2015-09-00; online 2015-08-01]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structure of the Glycosyltransferase Ktr4p from Saccharomyces cerevisiae.
Possner DD, Claesson M, Guy JE
PLoS ONE 10 (8) e0136239 [2015-08-21; online 2015-08-21]
Protein Science Facility (PSF)
PubMed DOI Crossref
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.
Carter M, Jemth AS, Hagenkort A, ..., Helleday T, Stenmark P
Nat Commun 6 (-) 7871 [2015-08-04; online 2015-08-04]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation.
Tan TC, Kracher D, Gandini R, ..., Ludwig R, Divne C
Nat Commun 6 (-) 7542 [2015-07-07; online 2015-07-07]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate
Trésaugues L, Lundbäck T, Welin M, ..., Gräslund S, Nordlund P
PLoS ONE 10 (6) e0131507 [2015-06-29; online 2015-06-29]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF)
PubMed DOI Crossref
Structure of the nuclease subunit of human mitochondrial RNase P.
Reinhard L, Sridhara S, Hällberg BM
Nucleic Acids Res. 43 (11) 5664-5672 [2015-06-23; online 2015-05-09]
Protein Science Facility (PSF)
PubMed DOI Crossref
Processing of protein ADP-ribosylation by Nudix hydrolases.
Palazzo L, Thomas B, Jemth AS, ..., Helleday T, Ahel I
Biochem. J. 468 (2) 293-301 [2015-06-01; online 2015-03-20]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Crystal structures of the kinase domain of the sulfate-activating complex in Mycobacterium tuberculosis.
Poyraz Ö, Brunner K, Lohkamp B, ..., Schnell R, Schneider G
PLoS ONE 10 (3) e0121494 [2015-03-25; online 2015-03-25]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF)
PubMed DOI Crossref
Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein.
Karlberg T, Klepsch M, Thorsell AG, ..., Linusson A, Schüler H
J. Biol. Chem. 290 (12) 7336-7344 [2015-03-20; online 2015-01-31]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa.
Schmidberger JW, Schnell R, Schneider G
Acta Crystallogr. D Biol. Crystallogr. 71 (Pt 3) 721-731 [2015-03-00; online 2015-02-26]
Protein Science Facility (PSF)
PubMed DOI Crossref
High-resolution crystal structure of a polyextreme GH43 glycosidase from Halothermothrix orenii with α-L-arabinofuranosidase activity.
Hassan N, Kori LD, Gandini R, ..., Divne C, Tan TC
Acta Crystallogr F Struct Biol Commun 71 (Pt 3) 338-345 [2015-03-00; online 2015-02-19]
Protein Science Facility (PSF)
PubMed DOI Crossref
Biochemical and structural characterization of a thermostable β-glucosidase from Halothermothrix orenii for galacto-oligosaccharide synthesis.
Hassan N, Nguyen TH, Intanon M, ..., Divne C, Tan TC
Appl. Microbiol. Biotechnol. 99 (4) 1731-1744 [2015-02-00; online 2014-09-01]
Protein Science Facility (PSF)

Year 2014

PubMed DOI Crossref
A novel cytosolic NADH:quinone oxidoreductase fromMethanothermobacter marburgensis
Ullmann E, Tan TC, Gundinger T, ..., Divne C, Spadiut O
Biosci. Rep. 34 (6) 893-904 [2014-12-23; online 2014-12-23]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme.
Dobritzsch D, Wang H, Schneider G, Yu S
Biochem. J. 462 (3) 441-452 [2014-09-15; online 2014-06-21]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural basis for regulation of the human acetyl-CoA thioesterase 12 and interactions with the steroidogenic acute regulatory protein-related lipid transfer (START) domain.
Swarbrick CM, Roman N, Cowieson N, ..., Lehtiö L, Forwood JK
J. Biol. Chem. 289 (35) 24263-24274 [2014-08-29; online 2014-07-09]
Protein Science Facility (PSF)
PubMed DOI Crossref
Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.
Guettou F, Quistgaard EM, Raba M, ..., Löw C, Nordlund P
Nat. Struct. Mol. Biol. 21 (8) 728-731 [2014-08-00; online 2014-07-30]
Protein Science Facility (PSF)
PubMed DOI Crossref
Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family.
Pinto AF, Schüler H
Curr. Top. Microbiol. Immunol. 384 (-) 153-166 [2014-07-13; online 2014-07-13]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural and biochemical characterization of human PR70 in isolation and in complex with the scaffolding subunit of protein phosphatase 2A.
Dovega R, Tsutakawa S, Quistgaard EM, ..., Löw C, Nordlund P
PLoS ONE 9 (7) e101846 [2014-07-09; online 2014-07-09]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.
Löw C, Quistgaard EM, Kovermann M, ..., Balbach J, Nordlund P
Biol. Chem. 395 (7-8) 881-889 [2014-07-00; online 2014-07-09]
Protein Science Facility (PSF)
PubMed DOI Crossref
Crystal structure of human CRMP-4: correction of intensities for lattice-translocation disorder
Ponnusamy R, Lebedev AA, Pahlow S, Lohkamp B
Acta Crystallogr. D Biol. Crystallogr. 70 (6) 1680-1694 [2014-06-01; online 2014-05-30]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Structure and inhibition of mouse leukotriene C4 synthase.
Niegowski D, Kleinschmidt T, Ahmad S, ..., Rinaldo-Matthis A, Haeggström JZ
PLoS ONE 9 (5) e96763 [2014-05-08; online 2014-05-08]
Chemical Biology Consortium Sweden (CBCS) [Service] Protein Science Facility (PSF)
PubMed DOI Crossref
Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.
Trésaugues L, Silvander C, Flodin S, ..., Berglund H, Nordlund P
Structure 22 (5) 744-755 [2014-05-06; online 2014-04-08]
Protein Science Facility (PSF)
PubMed DOI Crossref
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Gad H, Koolmeister T, Jemth A, ..., Berglund UW, Helleday T
Nature 508 (7495) 215-221 [2014-04-10; online 2014-04-02]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF)
PubMed DOI Crossref
Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors.
Liscio P, Carotti A, Asciutti S, ..., Pellicciari R, Camaioni E
J. Med. Chem. 57 (6) 2807-2812 [2014-03-27; online 2014-02-18]
Protein Science Facility (PSF)
PubMed DOI Crossref
Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.
Stsiapanava A, Olsson U, Wan M, ..., Rinaldo-Matthis A, Haeggström JZ
Proc. Natl. Acad. Sci. U.S.A. 111 (11) 4227-4232 [2014-03-18; online 2014-03-05]
Advanced Mass Spectrometry Proteomics Protein Science Facility (PSF)
PubMed DOI Crossref
Epitope-specific antibody response is controlled by immunoglobulin V(H) polymorphisms.
Raposo B, Dobritzsch D, Ge C, ..., Schneider G, Holmdahl R
J. Exp. Med. 211 (3) 405-411 [2014-03-10; online 2014-02-19]
Protein Science Facility (PSF)
PubMed DOI Crossref
ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics.
Marteyn BS, Karimova G, Fenton AK, ..., Sansonetti PJ, Tang CM
MBio 5 (2) e00022-e00014 [2014-03-04; online 2014-03-04]
Protein Science Facility (PSF)
PubMed DOI Crossref
Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism.
Niegowski D, Kleinschmidt T, Olsson U, ..., Rinaldo-Matthis A, Haeggström JZ
J. Biol. Chem. 289 (8) 5199-5207 [2014-02-21; online 2013-12-25]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural and functional insights into peptidoglycan access for the lytic amidase LytA of Streptococcus pneumoniae.
Mellroth P, Sandalova T, Kikhney A, ..., Henriques-Normark B, Achour A
MBio 5 (1) e01120-e01113 [2014-02-11; online 2014-02-11]
Protein Science Facility (PSF)
PubMed DOI Crossref
Product formation controlled by substrate dynamics in leukotriene A4 hydrolase.
Stsiapanava A, Tholander F, Kumar RB, ..., Haeggström JZ, Rinaldo-Matthis A
Biochim. Biophys. Acta 1844 (2) 439-446 [2014-02-00; online 2013-12-18]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural basis for binding of fluorinated glucose and galactose to Trametes multicolor pyranose 2-oxidase variants with improved galactose conversion.
Tan TC, Spadiut O, Gandini R, Haltrich D, Divne C
PLoS ONE 9 (1) e86736 [2014-01-21; online 2014-01-21]
Protein Science Facility (PSF)
PubMed DOI Crossref
The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold.
Schulte T, Löfling J, Mikaelsson C, ..., Henriques-Normark B, Achour A
Open Biol 4 (-) 130090 [2014-01-15; online 2014-01-15]
Protein Science Facility (PSF)
PubMed DOI Crossref
RipD (Rv1566c) from Mycobacterium tuberculosis: adaptation of an NlpC/p60 domain to a non-catalytic peptidoglycan-binding function.
Böth D, Steiner EM, Izumi A, Schneider G, Schnell R
Biochem. J. 457 (1) 33-41 [2014-01-01; online 2013-10-11]
Protein Science Facility (PSF)

Year 2013

PubMed DOI Crossref
Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3.
Lindgren AE, Karlberg T, Ekblad T, ..., Schüler H, Elofsson M
J. Med. Chem. 56 (23) 9556-9568 [2013-12-12; online 2013-11-06]
Protein Science Facility (PSF)
PubMed DOI Crossref
Substrate specificity and oligomerization of human GMP synthetase.
Welin M, Lehtiö L, Johansson A, ..., Gräslund S, Nordlund P
J. Mol. Biol. 425 (22) 4323-4333 [2013-11-15; online 2013-07-03]
Protein Science Facility (PSF)
PubMed DOI Crossref
Discovery of an allosteric inhibitor binding site in 3-Oxo-acyl-ACP reductase from Pseudomonas aeruginosa.
Cukier CD, Hope AG, Elamin AA, ..., Gray DW, Schneider G
ACS Chem. Biol. 8 (11) 2518-2527 [2013-11-15; online 2013-09-11]
Protein Science Facility (PSF)
PubMed DOI Crossref
Metal-mediated crystallization of the xylose transporter XylE from Escherichia coli in three different crystal forms.
Quistgaard EM, Löw C, Moberg P, Nordlund P
J. Struct. Biol. 184 (2) 375-378 [2013-11-00; online 2013-09-26]
Protein Science Facility (PSF)
PubMed DOI Crossref
Nanobody mediated crystallization of an archeal mechanosensitive channel.
Löw C, Yau YH, Pardon E, ..., Steyaert J, Nordlund P
PLoS ONE 8 (10) e77984 [2013-10-21; online 2013-10-21]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural insights into substrate recognition in proton-dependent oligopeptide transporters.
Guettou F, Quistgaard EM, Trésaugues L, ..., Nordlund P, Löw C
EMBO Rep. 14 (9) 804-810 [2013-09-00; online 2013-07-23]
Protein Science Facility (PSF)
PubMed DOI Crossref
PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.
Lindgren AE, Karlberg T, Thorsell AG, ..., Elofsson M, Schüler H
ACS Chem. Biol. 8 (8) 1698-1703 [2013-08-16; online 2013-06-08]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural and biophysical characterization of the cytoplasmic domains of human BAP29 and BAP31.
Quistgaard EM, Löw C, Moberg P, ..., Maddi K, Nordlund P
PLoS ONE 8 (8) e71111 [2013-08-13; online 2013-08-13]
Advanced Mass Spectrometry Proteomics Protein Science Facility (PSF)
PubMed DOI Crossref
High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation.
Anandapadamanaban M, Andresen C, Helander S, ..., Moche M, Sunnerhagen M
Nat. Struct. Mol. Biol. 20 (8) 1008-1014 [2013-08-00; online 2013-07-16]
Protein Science Facility (PSF)
PubMed DOI Crossref
Enzymatic production of 'monoclonal stoichiometric' single-stranded DNA oligonucleotides.
Ducani C, Kaul C, Moche M, Shih WM, Högberg B
Nat. Methods 10 (7) 647-652 [2013-07-00; online 2013-06-04]
Protein Science Facility (PSF)
PubMed DOI Crossref
The crystal structure of the lumenal domain of Erv41p, a protein involved in transport between the endoplasmic reticulum and Golgi apparatus.
Biterova EI, Svärd M, Possner DD, Guy JE
J. Mol. Biol. 425 (12) 2208-2218 [2013-06-26; online 2013-03-26]
Protein Science Facility (PSF)
PubMed DOI Crossref
Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct Substrates.
Chen MW, Lohkamp B, Schnell R, Lescar J, Schneider G
PLoS ONE 8 (6) e66936 [2013-06-21; online 2013-06-21]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters.
Quistgaard EM, Löw C, Moberg P, Trésaugues L, Nordlund P
Nat. Struct. Mol. Biol. 20 (6) 766-768 [2013-06-00; online 2013-04-30]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase.
Lim SM, Chen D, Teo H, ..., Pervushin K, Nordlund P
J. Lipid Res. 54 (6) 1630-1643 [2013-06-00; online 2013-03-26]
Protein Science Facility (PSF)
PubMed DOI Crossref
Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains.
Forst AH, Karlberg T, Herzog N, ..., Schüler H, Lüscher B
Structure 21 (3) 462-475 [2013-03-05; online 2013-03-12]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structure of LdtMt2, an L,D-transpeptidase from Mycobacterium tuberculosis.
Böth D, Steiner EM, Stadler D, ..., Schnell R, Schneider G
Acta Crystallogr. D Biol. Crystallogr. 69 (Pt 3) 432-441 [2013-03-00; online 2013-02-16]
Protein Science Facility (PSF)

Year 2012

PubMed DOI Crossref
Unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics.
Allerbring EB, Duru AD, Uchtenhagen H, ..., Nygren PÅ, Achour A
Eur. J. Immunol. 42 (11) 2990-3000 [2012-11-00; online 2012-07-28]
Protein Science Facility (PSF)
PubMed DOI Crossref
High-resolution insights into binding of unfolded polypeptides by the PPIase chaperone SlpA.
Quistgaard EM, Nordlund P, Löw C
FASEB J. 26 (10) 4003-4013 [2012-10-00; online 2012-06-28]
Protein Science Facility (PSF)
PubMed DOI Crossref
Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening
Andersson CD, Karlberg T, Ekblad T, ..., Schüler H, Linusson A
J. Med. Chem. 55 (17) 7706-7718 [2012-09-13; online 2012-09-13]
Chemical Biology Consortium Sweden (CBCS) [Service] Protein Science Facility (PSF)
PubMed DOI Crossref
Inflammation-associated nitrotyrosination affects TCR recognition through reduced stability and alteration of the molecular surface of the MHC complex.
Madhurantakam C, Duru AD, Sandalova T, Webb JR, Achour A
PLoS ONE 7 (3) e32805 [2012-03-14; online 2012-03-14]
Protein Science Facility (PSF)
PubMed DOI Crossref
Tetrahydrodipicolinate N-succinyltransferase and dihydrodipicolinate synthase from Pseudomonas aeruginosa: structure analysis and gene deletion.
Schnell R, Oehlmann W, Sandalova T, ..., Singh M, Schneider G
PLoS ONE 7 (2) e31133 [2012-02-16; online 2012-02-16]
Protein Science Facility (PSF)
PubMed DOI Crossref
High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C.
Willander H, Askarieh G, Landreh M, ..., Knight SD, Johansson J
Proc. Natl. Acad. Sci. U.S.A. 109 (7) 2325-2329 [2012-02-14; online 2012-02-07]
Protein Science Facility (PSF)
Publications 9.5.0